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Apr 1 – 5, 2019
Fairmont Château Laurier Hotel
UTC timezone

Tuning of the Radium biodistribution by dietary supplements in a <i>CD1</i> mice model.

Not scheduled
Fairmont Château Laurier Hotel

Fairmont Château Laurier Hotel



Dr Ján Kozempel (CTU in Prague)


Although 223RaCl2 has been approved for the treatment of bone metastases originating from mCRPC (EMA, FDA and others), further data on 223Ra biodistribution and possible metabolism tuning are needed particularly after the discovery of increased risk of death and fractures due to the interactions of 223Ra with abiraterone, prednisone/prednisolone treatment. Thus we report here the results of biodistribution study with 223RaCl2 applied intravenously to a healthy female CD1 mice fed with various dietary supplements - vitamin D and CaCl2 or with co-treatment with zoledronic acid. Ex vivo biodistributions were determined in major organs in 24 and 96 h. p.i. Our results indicate that the vitamin D and CaCl2 supplements and co-treatment with zoledronic acid have direct impact on Radium biodistribution and elimination kinetics. We speculate that under optimized conditions the treatment of bone metastases may become more efficient and safer compared to application of 223RaCl2 only.
Funding Agency Technology Agency of the Czech Republic, grant No.: TA03010027.
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Presentation Type Contributed Oral

Primary author

Dr Ján Kozempel (CTU in Prague)


Ms Ekaterina Kukleva (CTU in Prague) Ms Jana Merhautová (UJV Rež) Ms Karolína Ficenzová (UJV Řež) Ms Ludmila Jandová (UJV Řež) Dr Martin Vlk (CTU in Prague) Ms Petra Suchánková (CTU in Prague)

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