Speaker
Description
The design of a 3-sector high-resolution Multi-Turn Time-Of-Flight Mass Analyzer (MT-TOF MA) with a diameter of 300 mm and a flight path of ~30 m at 46 turns is presented. The analyzer has rotational and mid-plane symmetry of the main electrodes. It includes lower and upper polar-toroidal sectors S1 and S3, toroidal sector S2 located in the mid-plane, a pair of polar lenses for lateral focusing and a pair of conical lenses for longitudinal focusing. The open reference trajectory allows retaining the full range of masses of injected ions. Several analyzers of this type with a diameter of 500 mm or more have been designed, built and tested previously [1-3]. A mass resolving power of ~210 k (fwhm) was demonstrated over a flight path of ~50 m (myoglobin, ~17,000 Da, 15+, m/z ~1130 Th) [2]. The need for a "desktop" size instrument stimulated development of the presented small-size analyzer. The analyzer has two operating modes: forward (23 turns, internal detector) and reversing (46 turns, external detector). In the reversing mode, additional segments embedded into the external S2 electrode have to be used to provide focusing in the azimuthal (drift) direction. According to numerical simulations, m/dm in the reversing mode is ~75-80 k (fwhm) for ions extracted from an ion trap and accelerated to 8 keV. For a MALDI source, m/dm can be slightly higher, up to ~100 k (fwhm), due to the smaller transverse emittance of injected beams. The analyzer can be used for fast and accurate mass measurements up to at least several thousand Dalton. In this conference, we will present overview of the analyzer design studies including results of ion optics simulations.
References
[1] V. Shchepunov, M. Rignall, R. Giles and H. Nakanishi, A high resolution multi-turn TOF mass analyzer. In: Proc. of the 63rd ASMS Conf, St. Louis, MO, May 31 - June 4, 2015, MP092.
[2] Y. Tateishi, H. Miura, H. Morinaga, K. Kimura, T. Iida, J. Nakazono, M. Nishiguchi, O. Furuhashi, D. Okumura, Y. Yamaguchi, S. Uchiyama, Analyses of biopharmaceuticals using high-resolution multi-turn TOF-MS system. In: Proc. of the 71st ASMS Conf, Houston, TX, June 4 - 8, 2023, WP042.
[3] V. Shchepunov, M. Rignall, R. Giles, R. Fujita, H. Waki, and H. Nakanishi, A high resolution multi-turn TOF mass analyzer. International Journal of Modern Physics A, Vol. 34, No. 36, 1942005 (2019).
| Email address | vyacheslav.shchepunov@srlab.co.uk |
|---|---|
| Funding Agency | Shimadzu Corp. |
| Classification | Ion optics and spectrometers |
